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From the National Prescription Registry, we obtained the Defined Daily Doses (DDD) variable, which is based on the assumed average maintenance dose per day for a drug used for its main indication in adults, according to the World Health Organization Collaborating Centre for Drug Statistics Methodology ( Of note, exposure to metformin, the exposure drug, and the control drug was assumed to be continuous between initiation and end-of-treatment

Nuclear factor erythroid 2-related factor (Nrf2) is also a regulator of oxidative stress, involved through the transcription of antioxidant detoxification genes (206)

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doi: 10.1016/S2213-8587(19)30423-1 89 BasalayMVDavidsonSMYellonDM

heparin (extensive bleeding and blood loss, prominent fall in platelet count, drastic prolongation of PT-, APTT-, TT- values) or warfarin (extensive bleeding and blood loss, prominent fall in platelet count, drastic prolongation of PT-, APTT- values) (Table 2, Table 3 and Table 4)