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Pollution and smoking Exposure to air pollution, cigarette smoke, and other environmental stressors generates excess free radicals, which overwhelm glutathione reserves

The award was established to recognize the ideas of AAO members that have the potential to revolutionize orthodontic treatment or practice management

(PubMed) Yanaka A, Fahey JW, Fukumoto A, et al

Glutathione peroxidase 4 (GPX4) utilizes reduced GSH to convert lipid hydroperoxides to lipid alcohols via oxidizing GSH to oxidized glutathione (GSSG), thereby preventing the lipid peroxidation of the cell membrane and inhibiting ferroptosis (6)

They showed that IGF-1 delays the onset of behavioural symptoms and sustains life to a greater degree than GDNF