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This gradient on both sides of the BBB is strictly controlled by the different systems of AA transporters

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The protected amino acid derivatives used were Fmoc-Lys(Boc)-OH, Fmoc-D-Phe-OH, Boc-D-2Nal-OH, Boc-His(Trt)-OH and Boc-Aib-OH (Boc-Amino isobutyric acid)