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Pyy- deficient mice are hyperphagic and obese (130) while Pyy overexpression protects mice against obesity induced by HFDs or leptin deficiency (131)
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Guideline on Immunogenicity assessment of therapeutic proteins [Internet]
Cytotoxicity For Cytotoxicity detection, the cells were seeded into 96-well plates at a density of 2 10 4 cells/well
One mouse in vehicle group had supraphysiological glucagon levels outside the assay range and was omitted from analysis
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