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EDV significantly attenuated the loss of neurons in the hippocampus and medial prefrontal cortex (mPFC), microglial activation, oxidative stress damage, and astrocyte dysfunction via the Sirt1-Nfr2-HO-GPX4 pathway

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MS/MS Conditions Analytes were detected by MS/MS with an electrospray ionization (ESI) interface in negative multiple reaction monitoring

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Complex-driven H 2 O 2 production was measured using Amplex Red (Thermo Fisher), according to the manufacturers instructions but with the following modifications: after 24 h of BPM31510 treatment, the media were aspirated and the cells were washed with 1 MAS buffer