Since then, the idea of liver cirrhosis as a condition of IGF-I deficiency during adult age has been yearly consolidated from a number of publications establishing the origin of this lack from a decrease in GH receptors seen in cirrhotic livers[216] and a progressive reduction of liver synthesis capability from decreased hepatocellular mass in advanced stages[209]
Na literatura de investigao, este perfil estreito designado como comportamento "limpo" ou seletivo do secretagogo, sendo considerado a caracterstica distintiva definidora da substncia
Likewise, several dwarf models, including Ames, Snell and growth hormone receptor knockout (GHRKO) mice, are exceptionally long lived 4,5
doi: 10.2174/13816128130111
Falutz J, Allas S, Mamputu JC, et al