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This study demonstrated the importance of combined GLP-1R and GCGR signalling, as administration of the balanced co-agonist to Glp1r -/- mice led to hyperglycaemia, further demonstrating the necessity of GLP-1R and GCGR co-agonism to minimise this predicted side-effect

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DPP-4 inhibitors do not have significant effects on GI motility or appetite that are observed with more efficacious (DPP-4 resistant) GLP-1 agonists

Eli Lilly became the first healthcare or pharma company to reach a $1 trillion valuation