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FIGURE 5 2.4 Renal fibrosis Fibrous scar tissue generated by renal fibrosis (RF) replaces functional tissue, which impairs the regenerative ability of the kidneys and deteriorates renal function and tissue structure (Liu et al., 2018

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In overt hypothyroidism, elevated TSH and reduced free T4 or T3 concentrations are frequently accompanied by the accumulation of lipotoxic intermediates and activation of pro-fibrotic pathways

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