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With high energy output from mitochondria comes higher free radical and ROS production and greater susceptibility to oxidative stresswhich is where glutathione comes in again.* The sirtuin SIRT3a longevity-related protein that requires NAD+ for proper functioningis also involved here, helping to maintain hearing during aging by promoting glutathione-mediated antioxidant defense systems

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For more detailed guidance on how lifestyle impacts overall health, explore this related article on lifestyle choices