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A recent meta-analysis confirmed that CFS/ME is associated with distinct gut microbial signatures, including reduced levels of butyrate-producing bacteria and increased abundance of Enterobacteriaceae (Jurek and Castro-Marrero, 2024)

Methylcobalamin is a source of vitamin B12 that is highly absorbable

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Seasonal shifts in the day-night cycle may suppress immune function, explaining higher rates of colds and flu in winter and increased infection risk in the elderly