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Glutathione is compartmentalized throughout the cell, with 80-85% in the cytosol, 10-15% in mitochondria, and smaller amounts in the endoplasmic reticulum, nucleus, and peroxisomes

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We noticed, however, that the bottom part of subpocket C in the vicinity of the fragments found in the X-ray structures is formed by the hydrophobic portions of D325, Y479, A481, H538, G483, V469, T471 and is likely to prefer bulky hydrophobic substituents