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This epigenetic alteration results in cancer progression, drug resistance [34], metastasis and stemness induction [35, 36], metabolic alterations by affecting enzymes involved in the tricarboxylic acid cycle (TCA), and carbohydrate, amino acid, fatty acid, and nucleotide metabolism [35], hence opening the way to the generation of novel therapeutic strategies against lysine lactylation, not only regarding histones (Fig

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