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Introduction Obsessive compulsive disorder (OCD), the key example of obsessive-compulsive and related disorders (OCRDs), is a complex neuropsychiatric disorder affecting 2%4% of individuals and 16.9% of postpartum mothers ( First-line treatments are cognitive behavioral therapy/exposure response prevention (CBT/ERP) and pharmacotherapy with a serotonin reuptake inhibitor ( Strong emerging evidence suggests that inflammatory dysregulation of the CSTC circuit underlies the pathophysiology of OCD ( OCD is associated with a 1.83 increased risk of metabolic syndrome (MetS), obesity, type 2 diabetes (T2D), and cardiovascular disease ( Ulcerative colitis (UC) is a chronic, progressive, immune-mediated inflammatory bowel disease (IBD) affecting approximately 5 million people worldwide ( UC is characterized by frequent bloody diarrhea, pain, fatigue, and progression, and more than 1/3 of patients require hospitalization or surgery