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According to American Gastroenterological Association guidelines, osmotic laxatives like polyethylene glycol (PEG 3350) are recommended as first-line treatment for tirzepatide-induced constipation, as they are generally safe for regular use and effectively draw water into the colon to soften stools

GLP-1, or glucagon-like peptide 1, is an amino acid peptide hormone that is produced in the gut as a result of eating food

Nat Med, 2019

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