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Phentermine can raise blood pressure and heart rate significantly, making it unsafe for patients with cardiovascular disease or uncontrolled hypertension

Creatine is a molecule made primarily by the liver and kidneys

The impact of changed redoxin function on ferroptosis could also be based on secondary effects, e.g., the increase in superoxide formation upon loss of mitochondrial redoxins [90,91] or activation of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway [92,93] , a major regulator of transcription of antioxidant and anti-ferroptotic enzymes [65]

Based on these findings, GLP-1s should be prescribed together with a structured exercise program, aiming for regular strength training at least 3 times weekly plus at least 150 min of moderate-intensity aerobic exercise weekly to preserve muscle and bone mass [58,63,149,[165], [166], [167]]

doi:10.1002/aur.1691 101. Robertson, C