Endpoints: mechanical strength of the tendon junction, tissue histology, markers of fibroblast maturation
At week 36, the following differences were observed for change in 24-hour diastolic blood pressure from baseline relative to placebo therapy: Tirzepatide 5 mg: -2.0 (95% CI, -3.6 to -0.3) mmHg Tirzepatide 10 mg: -2.9 (95% CI, -4.5 to -1.3) mmHg Tirzepatide 15 mg: -0.5 (95% CI, -2.0 to 1.1) mmHg Further analysis suggested these results were consistent across subgroups defined by clinically relevant factors, including age, sex, BMI, and hypertension-related factors
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