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doi: 10.1124/jpet.106.105569

Absorbing enough through ingestion alone is dubious as our digestive process can be impacted by so many factors, from other nutrients consumed, to stress levels, and more

The primary risks are intensified nausea and vomiting, dangerous blood sugar drops (especially in diabetic patients), severe dehydration, increased intoxication sensitivity, and liver strain

10.3389/fphar.2019.00693 Front

[15] The resulting DSIP-CBBBP construct outperformed unmodified DSIP on neurotransmitter restoration in the mouse model, which is the clearest available statement of the problem: the peptide had to be rebuilt to get where it was supposed to act