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This tissue expansion process continues in phase 2, characterized by hormone responsiveness ( ESR1 , PGR ) and increased energy consumption (CKB , SCGB1D2 , HGD , IDO1 , ATP1A1 , PSAT1) [11] (Fig

The expression of genes related to DNA damage was changed in the cartilage of KBD patients 130,131

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This underscores the need for advanced research methodologies capable of addressing the complexity of translating preclinical findings into clinically validated treatments for AD using natural compounds (Ma et al., 2024b)