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Pharmacological characterization To examine whether the potent weight loss observed in vivo after GLP-1MK-801 treatment is attributable to pharmacological synergy between GLP-1 and MK-801 or consequential to altered pharmacokinetic properties of the parent GLP-1 analogue, we designed and synthesized a conjugate comprising an inactive MK-801 surrogate 22 (Supplementary Fig

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Indeed, excess mROS activates the NLRP3 inflammasome by upregulating IL-1 and IL-18 levels, further exacerbating inflammatory reactions within these cells (93)

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