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37 An innovative development in the treatment of acid-related diseases, including GERD, is the introduction of H + ,K + -ATPase inhibitors, known as potassium-competitive acid blockers (P-CABs)

Entresto (sacubitril/valsartan) Disease area(s): Cardiovascular Manufacturer(s): Novartis 2024 Sales (USD): $7.82 billion Why it sold so well: In 2024, Novartis heart failure medication, Entresto, had remarkable sales growth, generating $7.8 billion in revenue, a 31% increase over the previous year

[1] [2] It is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist

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These pest molecules include oxidants and toxic metals, and well discuss them more in the next section about how glutathione binds to these types of molecules