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In wild-type mice, Cx32 abundance in hepatocytes decreased substantially as early as 1-h post-APAP treatment, reaching a 20% reduction compared to the steady-state or control group

This can help in reducing dark spots, hyperpigmentation, and uneven skin tone, resulting in a brighter and more radiant complexion

Compound 14 should be singled out from the others, since it shows good inhibitory activity (IC 50 = 3.56 M), which is almost 2.5 times more effective than allopurinol (IC 50 = 7.86 M), a drug that has already been consolidated in the treatment of hyperuricemia (Figure 7)

Zhang, X.-X