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Study participants included in one or more analyses had been enrolled in selected insurance plans or health systems for at least one year, were free of at least one outcome at baseline, completed a minimum number of follow-up assessments, and either: 1) filled multiple extended-release/long-acting opioid analgesic prescriptions during a 90 day period (n=978)

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Vitamin B12 is water-soluble it quickly dissolves in water and does not remain in the body, being eliminated through urine within 2472 hours depending on physical activity and water intake

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