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At week 8, 51.6% patients treated with ALC met the primary endpoint, compared with 23.1% of patients in the placebo group

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This molecule has shown its place in all stages of diabetes and in addition to various antidiabetic drugs as seen in the PIONEER clinical trial programme

Each subunits active site is buried deep within the protein structure, and is only accessible from the surface via channels lined with hydrophobic amino acids

The rationale behind this strategy is that pyridostigmine is a reversible carbamate inhibitor of acetylcholinesterase, which at doses used to treat myasthenia gravis, will occupy and protect a substantial percentage of acetylcholinesterase from being able to bind irreversibly with soman