does semaglutide cause tiredness Make You Sleepy? Fatigue Facts and Management Semaglutide Fatigue: Why It Happens

Some patients may tolerate one medication better than the other

Sleep and stress : Inadequate sleep (less than 7 hours nightly) disrupts hormones that regulate hunger and satiety, including leptin and ghrelin, potentially counteracting semaglutide's effects

Clinical evidence shows fewer than 20% of people successfully maintain significant weight loss without medication after treatment ends

However, results vary from person to person depending on the dose, diet, physical activity, and starting body weight

Rare but serious side effects, such as pancreatitis or gallbladder problems, can occur, so careful screening and ongoing monitoring are essential