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For PROTACs specifically, additional challenges include resistance mechanisms, limited tissue-specificity of available E3 ligases, poor oral bioavailability, and risks of off-target protein degradation in non-target tissues

The effects of vitamins, minerals, and physiological as well as plant secondary metabolites from nutrition or nutritional supplements on hair loss are still barely understood in detail and thus more scientific evidence is needed here [8] [11] [12]

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Albano E., Bellomo G., Parola M., Carini R., and Dianzani M