It is acceptable to alternate days of use for sensitive individuals
If IGF-1 drops 1520% from peak despite protocol adherence, receptor downregulation is likely this signals the need to restructure the stack or implement a washout period
The semaglutide versus tirzepatide comparison is worth reviewing because tirzepatide, a dual GLP-1/GIP agonist, shows even greater weight loss results at 20.2% average body weight reduction
General inflammatory markers: High-sensitivity CRP (hs-CRP), the most responsive general marker Erythrocyte sedimentation rate (ESR) Fibrinogen Condition-specific markers: Rheumatoid arthritis: RF, anti-CCP, DAS28 score Hashimoto thyroiditis: TPO antibodies, thyroglobulin antibodies, TSH Psoriasis: PASI score, BSA involvement IBD: Fecal calprotectin, SES-CD or Mayo score Lupus: ANA, anti-dsDNA, complement C3/C4 Cytokine panels (when available): TNF-alpha IL-6 IL-1 beta IL-17 (particularly relevant for psoriasis and spondyloarthritis) The recommendation from most practitioners is baseline testing before starting, a 4 to 6 week interim check, and a full reassessment at 12 weeks
200 ml still water - best taken at least 30 minutes before a meal
