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Disrupting this pathwayeither by severing kidney sensory nerves, selectively deleting the angiotensin II type 1a receptor (AT1a) in the subfornical organ (SFO), or using optogenetics to silence the kidney-SFO or SFO-paraventricular nucleus (PVN) connectionsreduces sympathetic output, which in turn diminishes structural damage and functional impairment in the kidneys and heart in these models of CKD and heart failure (Cao et al., 2023)
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Subcutaneous Drug Injection Review (PMC) Pharmacologic considerations of the subcutaneous route Related research, protocols, and guides Explore the available research context, protocol variants or comparisons, and practical guides
EtxeberriaUFernndez-QuintelaAMilagroFIAguirreLMartnezJAPortilloMP
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