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Once-demyelinated areas may still present themselves as scarred tissue

85 In conclusion, complex interactions exist between immune cells and mediators in COPD pathogenesis, which regulate the inflammatory response and maintain the immune balance, thereby influencing disease development and progression 86 (Figure 4)

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Calculation of HOMA-IR index The homeostatic model assessment of insulin resistance (HOMA-IR) was calculated using the formula: HOMA-IR = [fasting insulin (mU/L) fasting glucose (mg/dL)/405] 75

Research suggests that it may influence neural activity, vascular responses, and cellular pathways