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Specifically, the system consisted of a Thermo Q-Exactive in line with an electrospray source and an Ultimate3000 series HPLC consisting of a binary pump, degasser and auto-sampler outfitted with an Xbridge Amide column (Waters) (dimensions: 3.0 100 mm and a 3.5-m particle size)
Traumatic stress significantly downregulated the expression of miRNA-598-3p in the BLA, increasing the susceptibility of males to fear conditions (Jones et al., 2019)
doi:10.1155/2015/314560 7
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Second, cerebrolysin inhibits glycogen synthase kinase-3 beta (GSK3beta), an enzyme whose overactivity suppresses BDNF production and promotes tau phosphorylation, a hallmark of Alzheimer pathology
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