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Of note, only small number of sudies investigated this outcome with heterogenity in inclusion criteria among study populations, and differences in AOX combinations and SDF assays used

Early GI symptoms appear in approximately 40% of users but remain mild

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In animal models, inoculation of pre-formed -synuclein fibrils or pathogenic -synuclein species induces time-dependent appearance of phosphorylated -synuclein pathology in the dorsal motor nucleus of the vagus and downstream brain regions

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