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Over the past two decades, there were only symptomatic treatment available for AD like cholinergic inhibitors and NMDA antagonists, which only relieved the symptoms of the disease without modifying the underlying pathophysiology [309]

Typically, the skin-lightening effects last for a few months, and maintenance treatments are often needed to preserve the results over the long term.

Acknowledgements We are grateful to the patient Ms

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Die Behandlung mit Somatotropinanaloga ermglicht es Kindern mit Wachstumshormonmangel in vielen Fllen, eine normale Krpergre zu erreichen