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Although cellular abnormalities in the initiating cells of kidney stone may occur in the pRTECs, both Randall's plaque and plug occur in the more distal renal tubules, and thus the links between pRTECs and more distal events remain unclear

However, researchers repeatedly recognize these potential effects: Lower glucose production in the liver Anti-inflammatory effects Anticancer effects Metformin is a weak complex I inhibitor (a part of the mitochondria), so it might activate stress responses that fight off disease

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Nosaka T, Murata Y, Takahashi K, Naito T, Ofuji K, Matsuda H, Ohtani M, Hiramatsu K, Imamura Y, Goi T, Nakamoto Y

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