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You need the physiologic stimulus, the tension on the muscle

Obesity development in PWS is driven by dysfunction in neural pathways involved in satiety and reward, dysregulation in hormones regulating satiety and food intake, altered body composition and reduced energy expenditure, as well as the presence of various hormone deficiencies

It only offers compounded medications, which arent FDA approved and may not be available in all states

According to the Mayo Clinic, supplementing with B12 injections without having a deficiency will not induce weight loss, but is not likely to cause harm either