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Bioglutide (NA-931) presents a novel quadruple-agonist mechanism that is scientifically ambitious, targeting GLP-1, GIP, glucagon, and IGF-1 receptors in a single oral molecule

The MHRA-approved dosing begins at 0.6 mg daily as an initiation dose (to improve gastrointestinal tolerability rather than for glycaemic control), gradually increasing to a maintenance dose of 1.2 mg or 1.8 mg depending on individual response and tolerability

Retatrutide is a synthetic investigational peptide studied as a triple agonist of the GIP, GLP-1, and glucagon receptors

Pancreatitis is another rare but serious potential adverse effect of GLP-1 receptor agonists

In the skin, patients with diabetes are more likely to appear aged and have a skin infection or foot ulcers, which is accompanied by fragmented collagens and dysregulated dermal connective tissues (78)