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Any medication that affects glucose, lipid metabolism, growth hormone signaling, or beta-adrenergic activity could in theory interact, but evidence is absent

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2.1 The effects of periodontitis on pathogenic bacteria and metabolites Periodontal pathogens aggregate on teeth through dental plaque biofilms, which create a relatively stable habitat for bacteria

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The body gradually develops tolerance to the medication, reducing the intensity of the local immune response with each exposure