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By pumping the accumulated, unbound cytosolic catecholamines backward across the plasma membrane and safely into the extracellular synaptic space, the neuron is able to maintain its free cytoplasmic neurotransmitter levels below toxic thresholds , directly protecting itself from oxidative cell death and preserving neuronal viability (Underhill et al., 2021)

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But studies showed that while immobilization helped alleviate the pain of such injuries, it also contributed to a general weakening of the ligaments and predominance of adhesive capsulitis, where the arm is frozen (frozen shoulder) and can no longer be lifted