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- when there is risk of torsades de pointes, for example in patients with prolonged QT, concomitant administration of other medications that produce torsades de pointes (amiodarone, quinidine, bepridil, IV erythromycin, halofrantine, pentamidine, sparfloxacin, sultopride, vincamine, betrilio, disopyramide, sotalol, etc)

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Ethylene and SA content were determined as previously described 7,80

If further dose escalation is needed, the dose can be increased to 1.0 mg once weekly for four weeks