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But the strength of a mechanistic argument does not override the need for careful clinical judgment, and both therapeutic approaches carry risk profiles that must be understood and managed individually

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Fox serves as a principal investigator for clinical trials sponsored by both Novo Nordisk and Eli Lilly

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Addressing these gaps will require well-designed longitudinal studies and pediatric-specific clinical trials to establish the safety, durability, and optimal positioning of incretin-based therapies in adolescent obesity management