Both can cause injection site reactions (e.g., swelling and redness)
It may seem surprising that GLP-1(9-36) seemingly failed to lower plasma glucagon compared to saline controls in these experiments but it should be noted the more pronounced hypoglycemia should have triggered a much stronger increase in plasma glucagon (28) and the absence of such an effect is therefore indicative of an inhibitory effect
Since then, new classes of glucose-lowering drugs have been introduced for the treatment of T2D, namely di-peptidyl peptidase-4 inhibitors (DPP-4is), sodium-glucose cotransporter-2 inhibitors (SGLT2is), glucagon-like peptide 1 receptor agonists (GLP-1 RAs) and, since 2022, tirzepatide, a dual glucosedependent insulinotropic polypeptide (GIP)/GLP-1 RA
See links to the relevant research below
Importantly, menstrual disruption appeared more frequently in participants experiencing faster weight loss rates