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Reduced levels of GSH are observed in PD (Mandal et al., 2023),with GSH depletion considered a crucial factor in the dysfunction of dopaminergic (DA) neurons, rendering them more susceptible to oxidative damage (Smeyne and Smeyne, 2013

In addition, the researchers propose, other factors also may contribute, such as certain medications, minor illnesses (especially gastrointestinal conditions) and perhaps changes in the microbiome that might deplete carnitine from the body

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