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Macia L, Rao PT, Wheway J, Sierro F, Mackay F, Herzog H

however, with prolonged hypoxic stress, excessive oxidative stress further stimulates the immune system in the body and releases large amounts of inflammatory factors that accumulate in the body (Pu et al., 2022)

Reported side effects included: Nausea (most common, particularly during dose escalation) Vomiting Diarrhea Constipation Decreased appetite (this is also the mechanism, so it is both a side effect and the goal) Discontinuation due to side effects in the Phase 2 trial was around 16% in the highest dose group

Pirfenidone in progressive pulmonary fibrosis: a systematic review and meta-analysis