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Inserting the needle too shallow risks depositing medication in the dermis (upper skin layer), causing surface irritation and reduced absorption

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Compared with short-acting GLP-1 RAs, which essentially reduce postprandial glucose by delaying gastric emptying, long-acting GLP-1 RAs often result in constant medication exposure and maintain relative concentrations over 24 h and/or over a week, even if the interval between parenteral therapy is a day or a week [27]