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Long periods of fasting without sufficient protein intake or dietary variety can lead to nutritional inadequacy, clinical nutrient deficiencies, loss of fat-free mass, and reduced resting energy expenditure [291]

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Filipin staining confirmed decreased islet cholesterol content (Figure 1G), which correlated with increased exendin-4-induced cAMP responses (Supplementary Figure 1B), and exendin-4-induced insulin secretion (Figure 1H, I) in simvastatin-exposed islets

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Countries backed by high healthcare expenditure, increasing awareness of obesity, and sustained efforts in clinical adoption of advanced therapies contribute to the expansion