Wang X, Catt S, Pangestu M, Temple-Smith P
When we start treatment, I always remind patients of this: We are filling the tank, but you should not leave the tap underneath open. Getting maximum benefit from glutathione therapy is closely related not only to the procedure performed in the clinic but also to the patients lifestyle
Disrupted iron homeostasis in the brain has been increasingly implicated in the pathology of many CNS diseases, where excessive iron accumulation can lead to oxidative stress, neuroinflammation, and ferroptotic cell death in vulnerable brain regions (Salvador et al., 2010)
A bunch of mitochondrial proteins have succinylation modification, such as UCP1 in thermogenic function, GLUD1 in glutamate metabolism, SDH in ETC, the TCA cycle, GLS2 and CPS1 in glutaminolysis, ECHA and VLCAD in FAO, HMGCS2 in ketogenesis and SHMT2 in serine catabolism
10.1016/j.cmet.2006.07.006 Cell Metab