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Shults, 2003) with no adverse effects (Galpern and Cudkowicz, de novo PD patients during phase II clinical trials although no follow up study has been published (Shults et al., 2002)

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The multitude of favorable effects of GLP-1 RAs have led to their increased use in other patient populations, including those with cardiometabolic disease but without T2DM (eg, prediabetes, 18 , 19 hypertension, 20 metabolic dysfunction-associated steatohepatitis 21 ), cardiovascular disease,22, 23, 24 chronic kidney disease, 25 and sleep apnea