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called 'active vitamin B 12 '), and homocysteine (5)

In humans, GABA concentrations or GABA-receptor densities have been found to be reduced in epileptic patients [100,101], and reduced binding to benzodiazepines has been demonstrated in the mesial temporal lobe on positron emission tomographic scanning [102,103] meaning reduced inhibitory capacity and responsiveness to pharmacological activation

Epigallocatechin-3-gallate activates Nrf2/HO-1 signaling pathway in cisplatin-induced nephrotoxicity in rats

doi: 10.1080/19932820.2018.1500346 39 TuSZhangXLWanHFXiaYQLiuZQYangXHet al

Eng et al., J Biol Chem, 1992 Parkes et al., Diabetes Care, 2013 #GLP1 #DrugDiscovery #FromBenchToBedside #NephMadness #MedicalEducation #Endocrinology #Nephrology GLP-1 Receptor Agonists from Gila Monster Venom GLP-1: from lizard venom to modern medicine One of the most fascinating origin stories in pharmacology