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Clinical pharmacokinetics of oral semaglutide: analyses of data from clinical pharmacology trials

McIntyre RS, Powell AM, Kaidanovich-Beilin O, Soczynska JK, Alsuwaidan M, Woldeyohannes HO, et al

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A 2025 JAMA Network Open study found that semaglutide or tirzepatide was associated with increased risk of NAION and other optic nerve disorders, but the overall risk was low and prior findings have been inconsistent

However, its spectrum of activity is narrower than that of Ibrexafungerp, with limited data on efficacy against molds or rare fungal pathogens (Fung and Shirley, 2025)