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If a patient has neurological symptoms, the frequency might be every two months

However, semaglutide is contraindicated in individuals with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia type 2 (MEN2)

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A 2024 randomised trial in adults with elevated fracture risk found that semaglutide reduced hip bone mineral density by 2.6% and lumbar spine density by 2.1% at 52 weeks compared with placebo