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In contrast, a threonine residue at position 877 would be extremely unfavorable for 9-fluorocortisol binding, and the hydrophobic leucine at position 701 in the wild-type receptor would be unable to engage in the formation of this stabilizing hydrogen bond network

Begum MN, Mahtarin R, Ahmed S, Shahriar I, Hossain SR, Mia MW

Genome-to-genome analysis highlights the effect of the human innate and adaptive immune systems on the hepatitis C virus