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RELATED: Speeding Up Your Metabolism Support Micronutrients and Hormones Eberwein recommends considering hormone and micronutrient contexts: In midlife, unaddressed low testosterone, estrogen, or thyroid function can turn GLP-1 weight loss into a fast-track to sarcopenia. He recommends that people using GLP-1s routinely check and optimize their hormone, iron, and vitamin D and B 12 status, since these can quietly undermine energy, training tolerance, and muscle repair